If a patient contracts an infection while in the hospital, each day of hospitalization increases by 1 percent the likelihood that the infection will be multidrug-resistant, according to research presented at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) an infectious disease meeting of the American Society for Microbiology.
Researchers from the Medical University of South Carolina gathered and analyzed historical data from 949 documented cases of Gram-negative infection at their academic medical center. In the first few days of hospitalization the percentage of infections associated with Gram-negative bacteria classified as multidrug-resistant was about 20 percent and rose fairly steadily until four or five days, then jumped dramatically, peaking at over 35 percent at 10 days. Statistical analysis suggested an additional 1 percent risk per day of hospitalization. Read More >>
New Antimicrobial Strategy Silences NDM-1 Resistance Gene in Pathogens
Researchers have synthesized a molecule that can silence the gene responsible for severe antibiotic resistance in some bacteria. The research, presented at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), an infectious disease meeting of the American Society for Microbiology (ASM) could be a viable new strategy for treating resistant infections.
The focus of this new molecule is NDM-1 (New Delhi metallo-beta-lactamase-1) a gene carried by some bacteria that allows them to produce an enzyme called carbapenemase.
“NDM-1 confers bacterial resistance to all classes of beta-lactam (penicillin type) antibiotics including carbapenems, powerful antibiotics used when others fail,” says Bruce Geller of Oregon State University and author on the study. “NDM-1 has spread rapidly to many bacterial pathogens, including E. coli, Acinetobacter baumannii and Klebsiella pneumoniae. Many of these pathogens are resistant to multiple antibiotics, which limits treatment options.” Read More >>
Bacteria From Bees is a Potential Alternative to Antibiotics
Raw honey has been used against infections for millennia, before honey – as we now know it – was manufactured and sold in stores. So what is the key to its’ antimicrobial properties? Researchers at Lund University in Sweden have identified a unique group of 13 lactic acid bacteria found in fresh honey, from the honey stomach of bees. The bacteria produce a myriad of active antimicrobial compounds.
These lactic acid bacteria have now been tested on severe human wound pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and vancomycin-resistant Enterococcus (VRE), among others. When the lactic acid bacteria were applied to the pathogens in the laboratory, it counteracted all of them. Read More >>